Renal clearance is used to determine renal elimination mechanisms of a drug, which is the result of glomerular filtration, active tubular secretion and reabsorption. 肾清除率常用来表示药物在肾中的排除机制,它是肾小球滤过和肾小管分泌与重吸收的作用结果。
This would lead to an increase of the free fraction that would be subject to a fast renal clearance. 这将导致被肾脏快速清除的游离部分(分数)增加。
Measurement of effective renal plasma flow by plasma clearance of~ 131I-Hippuran using one or two blood sampling 用一或二份血样本~(131)I-OIH血浆清除法测定肾有效血浆流量
Relationship between renal function test and~ ( 99m) Tc-DTPA clearance rate 常用肾功能测定方法与~(99m)Tc-DTPA清除率的关系探讨
The following parameters were measured: effective renal plasma flow ( ERPF) assesed by 131I-O-sodium iodohippurate ( 131I-OIH) clearance rate; 利用131I-邻碘马尿酸钠测定有效肾血浆流量(ERPF);
Twenty refractory nephrotic patients were studied before and after prednison was used. Significant increase in urine protein excretion and effective renal plasma flow and endogenous creatinine clearance were observed. 通过对20例难治性肾病综合征患者使用激素前后的对照研究,发现使用激素以后,尿蛋白量显著增加,同时有效肾血浆流量及内生肌酐清除率也显著增加。
The effect of cadmium upon renal lysozyme clearance ( Clys) was observed in 19 rats, using lysozyme perfusion. 利用大鼠镉中毒性肾损害模型,观察了镉对溶菌酶肾脏清除率的影响。
The effect of cadmium upon renal lysozyme clearance 镉对溶菌酶肾脏清除率的影响
Conclusion GS may be present with severe hypocalcaemia and hypokalemic periodic paralysis; the renal clearance studies by diuretic administration may be of help in diagnosing Gitelman's syndrome, and the combined use of indomethacin with triamterene has good therapeutic effect. GS可伴有严重低钙血症、周期性麻痹,肾脏清除率试验在临床上可帮助诊断,消炎痛及氨苯蝶啶联合应用治疗有效。
Methods The GFR of 19 patients with different renal functions were examined using clearance of 99m Tc-DTPA and clearance of iohexol. Then the correlation of them was analyzed. 方法对19例不同肾功能的患者同时进行99mTc-DTPA清除率及碘海醇清除率的测定,以99mTc-DTPA清除率为标准方法,对两组结果进行相关分析。
The serum concentration obviously increased ( 12.4+ 1.1ug/ ml) in the aged and patients with cardiac insufficiency or renal insufficiency. The clearance rate of gentamicins decreased and the T1/ 2 was prolonged. 结果老年人伴有肾功能不全或心衰者,最高血药浓度明显增高(12.41±1.1μg/ml),药物在体内消除缓慢,T(1/2)明显延长,易发生毒性反应。
Methods Examined renal tubular function and glomerular filtration function in essential hypertension, after excluded renal hypertension by renal artery angiography and creatinine clearance. 方法通过肾动脉造影、内生肌酐清除率排除肾性高血压,检测入选的原发性高血压病患者的肾小球滤过功能指标和肾小管功能指标。
Cardiac hemodynamic and renal clearance experiments were performed after the last 24 h urine collection. The severity of the renal injury was semi-quantitatively assessed. 在收集完最后一次24h尿样后进行心脏血流动力学和肾脏清除率实验,用半定量的评分方法进行肾脏病理学检查。
CONCLUSION: The renal clearance of trans-tramadol was stereoselective. 结论:反式曲马朵及反式氧去甲基曲马朵的肾脏清除具有立体选择性。
Conclusion: Radial incision of renal parenchyma for treating complicated renal stones is characterized by little intraoperative bleeding, high stone clearance rate, slight impairment of renal function, and less complications. 结论:肾实质放射状切开取石术治疗复杂肾结石具有出血少、结石残留率低、肾功能损害小及并发症少的优点。
Influence of lower renal calyceal anatomy on the clearance of stones 肾下盏解剖对结石排出的影响
Conclusion Cystatin C is a sensitive index in monitoring glomerular filtration, which may be more accurate in evaluating renal function in combination with 24 h urine creatinine clearance. 结论CystatinC是肾小球滤过率监测中的一个较敏感的指标。联合应用CystatinC和24h尿内生肌酐清除率可以更准确地评估肾功能。
Conclusions: Stone-fetching therapy by opening kidney after hypothermic transient interruption of the renal artery has the advantage of simple, safe, high single time clearance rate, few postoperative complications and preservation of renal function. 结论:低温肾动脉阻断肾实质切开取石术具有操作简单、手术安全、取净率高、术后并发症少、肾功能保护好等优点。
Calcium content of renal tissue was significantly decreased and endogenic creatinine clearance were elevated. 给人参总皂甙后显著减少肾组织细胞中钙离子含量,同时提高内生肌酐清除值。
CONCLUSION The data suggest that the raised plasma DLIS levels in cirrhotic patients is in close relationship with the pathophysiological process of liver cirrhosis, and fluid-natrium overload and hepatic, renal dysfunction may result in abnormality of DLIS secretion, metabolism and clearance. 结论研究结果表明,血浆DLIS水平的改变与肝硬化的病理生理过程有密切关系,即肝硬化时的机体水钠超负荷状态及肝肾功能障碍可能导致DLIS的分泌、代谢及清除的异常或失调。
Hepatic encephalopathy ( HE) was evaluated by animals 'behaviors and EEGs, and functional renal failure by renal function indexes such as creatinine clearance ( Ccr), urine Na excretion volume ( UNaV). 根据动物一般表现和EEG判定HE,根据肾功能指标肌酐清除率(Ccr)、尿钠排泄量(U(Na)V)判定功能性肾衰的发生。
Renal insufficiency was defined as creatinine clearance rate ( Ccr) less than 80 ml/ min. 内生肌酐清除率(Ccr)<80ml/min为肾功能不全。
Results Total serum cholesterol and resistance indices of renal blood vessels increased significantly, while creatinine clearance rate and production of nitric oxide in the renal cortex decreased markedly in group HC and group H. 光镜观察肾组织学改变。结果HC组和H组血清总胆固醇及肾血管阻力指数显著性增加,而内生肌酐清除率、肾皮质一氧化氮含量显著性降低。
Chronic renal insufficiency disturbs antibiotics absorption, distribution, metabolism and renal clearance, which causes accumulation of antibiotics and/ or its metabolites and related symptoms, such as toxic effects of kidney, liver, bone marrow and nervous system. 慢性肾功能不全(CRI)对抗生素的吸收、分布、代谢和肾脏清除产生影响,导致血液中药物或其代谢产物蓄积和由此引起的并发症,例如肾脏、肝脏、骨髓和神经系统等毒性。
Correlation between the renal functions ( creatinine clearance rates) and the urine TGF-beta 1 relative concentrations after 1 year of renal transplantation were determined. 分析术后1年时尿TGFbeta1浓度与远期肾功能的关系。
Renal sodium handling with lithium clearance in the elderly 用锂清除试验对老年人肾脏钠转运功能的研究
Methods Thirty-nine cirrhotic patients were selected for evaluations of their renal function by radionuclide renogram, plasma AT ⅱ, endogenous creatinine clearance rate ( Ccr), serum sodium and 24 h urinary sodium excretion. 方法39例肝硬化患者作为研究对象,应用放射性核素肾图评价肾功能状态,同步测定血浆中ATⅡ、内生肌酐清除率(Ccr)、血钠以及24h尿钠排泄水平。
Inhibiting the drug efflux pump can increase the absorption of some orally drugs and decrease the renal clearance and hepatic-clearance. 抑制P-糖蛋白的药物溢出泵作用可有效地提高某些口服药物的吸收率,降低肝、肾清除率。
With time extending, the integrin β 1mRNA decreased gradually. Conclusion: 1. Albumin overload can cause rat renal function disorder. Came up with proteinuria, oliguria, creatinine clearance decreased, kidney index increased and followed by kidney injury. 2. 实验结论:1.白蛋白超负荷可以引起肾脏功能的紊乱,出现蛋白尿、少尿、肌酐清除率降低、肾脏指数增加等表现,进而引起肾脏损伤。
The combination of traditional Chinese medicine and modern medicine plays a certain role in treatment on chronic renal failure, particularly in improving the clinical symptom, increasing creatinine clearance rate, and in reducing blood creatinine and blood urea nitrogen. 前列地尔和肾康注射液在治疗慢性肾功能衰竭具有一定的作用,尤其在改善患者临床症状、提高肌酐清除率、降低血肌酐、血尿素氮等方面都具有确认的疗效。